Add me on the bandwagon concerning Jessica Rabbit.
As for my answer, Marge Simpson, Ash’s mom from Pokemon, and Rebecca from Tail Spin.
How you doin’!?
Should we be considering the revenge factor, here? I don’t particularly want a pissed-off, cuckolded Stan Smith looking to get even with me.
I am pleased to have found this:
I’ll go with Daisy Mae.
Not sure whether it’s been definitely established whether “cartoons” includes “comics,” but just in case I’ll throw in Juliette Burber.
I was assuming that Stan was dead myself.
Was he born on a rainy night?
And you even got them in the right order!
But is Mirage a mom?
I love it!
When Betty & Veronica were first…uh, invented, if they got pregnant, they couldn’t get a legal abortion. And they sure had a super-active social life, what with the Archies band and all, so…so during the summer comic hiatus, they might have “disappeared” for a while. That would make them moms, right?
I’d take either one.
I never watched a lot of “King of the HIll”, but I vaguely remember Dale Gribble’s wife (the one who was shacking up with John Redcorn) being kind of hot.
I may just have to keep you company there. maybe we can rope in Jessica Rabbit as well?
Christopher Robin’s mom.
Drew Saturday
Masane Amaha.
Helen Bennett/Mother-1
I’ll have to go with Blondie, but, she just barely edges out lil Abner’s wife Daisy Mae. Daisy has a larger rack, which is my first consideration, but there’s something about hillbillies that now grates on me. Plus, Blondie ain’t no slouch in the hooters department. So, she wins it.
A take-charge one, at that. And she seems to be able to get Jake to forget his neuroses and step up, so there must be something she does very well… 
Quinn must get it from somewhere.
Another vote for Annie Hughes, too.
Mighty Max’s mom from the Mighty Max cartoon.
No takers for Mama Bear from the Berenstain Bears??
Nobody’s mentioned the bootylicious Donna Tubbs Brown??
That would be one wild ride, I’ll bet. And the fact that she’s voiced by real-life hottie Sanaa Lathan doesn’t hurt either.
Lois griffin by a mile. There’s an episode with a brief scene where she’s dressed in BDSM gear.
MMmm…Mmmmm