Hmm, lots of good choices to go around with. From the movies I’ll have to say ChiCha from “The Emperor’s New Groove.” Even very pregnant she was damn hot!
From television once TWDuke mentioned Manjula I have a hard time thinking of other mothers.
Jessica Rabbit…
She’s not a mother, but she’s someone’s wife, and that’s close enough for me!
I find myself having thoughts about Dora the Explorer’s mommy that are best left unspoken…
When I saw this post, I started to ask about it. Then I realized I really, really didn’t want to know.
Man, the Internet creeps me out sometimes.
The mom from 9 Chickweed Lane is pretty hot. NOT the grandmother, the MOM.
From the PBS show George Shrinks, his Mom, Perdita Shrinks.
http://pbskids.org/georgeshrinks/characters/img/mom.gif
http://pbskids.org/georgeshrinks/fun/coloring/img/GS_CB_05.gif
http://pbskids.org/georgeshrinks/characters/card-mom.html
She looks nifty in a party dress.
She’s also an artist!
Maude Flanders.
Helen Bennet–AKA Mother One, from the Bionic Six. A sexy brunette.
Necrophilia for a cartoon character?
Mom Turner on the Fairly Oddparents. Rowr. I can fill the void!
Lois Griffin from Family Guy is attractive, too.
Kim Possible’s mom is pretty good looking.
Annie Hughes (from The Iron Giant)…
C’mon girls, we have to speak up and say which DILF!
For me it would be Xanatos, from Gargoyles!
I agree, especially when she wears animal print undies. I wouldn’t mind being in one of her fantasies. 
Milhouse’s mom.
Another vote for Lois Griffin. She’s plain Jane, but has that underlying sensuality that you know Peter can’t give her. OK, that sounded like a double entendre, but…
I met a woman that looked just like Dexter’s mom. Had to admit that I wanted that booty.
I always liked “Nancy’s” mom - although it always disturbed me that she was so “well-drawn” compared to Nancy, who looked like she was drawn by a 4th grader:
http://www.comics.com/comics/nancy/archive/images/nancy2004073198206.gif
I’ll second Thel Keane (the mom from Family Circus). Anyone here remember the DFC? I got maybe two captions accepted.
And another vote for Lois Griffin. It’s not just the rack or the caboose, it’s that big sexy brain of hers.
http://www.comics.com/comics/nancy/html/cast_Nancy.html tells us that this is Nancy’s Aunt Fritzi. Fritzi Ritz is former star of the strip.
Mrs. Moroboshi from *Urusei Yatsura[i/].
She’s an uber-MILF, since, as near as I can tell, (and I’ll admit to owning every episode, plus all the OVA’s and the movies) she doesn’t actually have a name of her own. (Even her pathetic husband calls her “Kaa-san” (Mother.)
Extra attractive since she has been shown to be susceptible to a combination of boyish looks and sweet talk such as “I want you to cook for me for the rest of my life,” even if that’s the only phrase in Japanese that you’ve been able to learn.
Score!