Well, there’s a live-action version of the show now. I’ve seen most of it, and…
…just…
…no.
If it were up to me, I’d make that acronym FILF.
Just, you know, because.
Hell I could make her a MILF for you in 10 seconds flat! eh? eh? elbows your side
nevermind.
I gotta say, I am astounded that thus far no one has mentioned about the only MTWEHACTF(Mother They Would Ever Have A Chance To Fuck).
Cartman’s mom.
Enjoy,
Steven
Another vote for Blondie. Hubba hubba!
Here’s somebody’s webpage titled Cartoon Girls I wanna Nail.
(Warning: contains very raunchy text)
Lois Pewterschmidt Griffin.
How about Nani, the big sister from Lilo & Stitch? She’s not actually a mom, but she is her sister’s legal guardian, so that’s sort of close. And I bet having those muscular legs wrapped around you would be an experience you wouldn’t soon forget…
Dennis the Menace has a pretty hot mom.
Pepper from Blue’s Clues is very hot.
I cannot believe nobody has mentioned Mrs. Shibata.
C’mon guys Archie and Jughead can’t have all the fun. Doesn’t anybody else want Betty AND Veronica? 
My God, cm, isn’t there some Orthodox prohibition against uttering vile puns?
I’d do Betty … but I’d be thinking of Wilma.
:struggles to avoid following up Red Dwarf quote:
Calvin’s mom.
slaps forehead
Well there’s my #1 choice now
Diogenes:
I haven’t seen any in the traditional interpretations. In fact, wordplay is quite common in the Talmud (granted, much less vile) 
“Puns - never apologize, never explain.” - Dogbert
What, no one has claimed the chance to make Betty Boop into Betty Bopped?
(I wouldn’t, either. I’m just surprised, that’s all.)
I don’t think they qualify on the “mom” factor.
What was Olive Oyl’s relationship to Swee’Pea?
I’m just curious, not that I think she’s hot - although she does have those long, agile limbs…