My dad swears he actually used to use this one…
:: go up to woman, put your hand on her shoulder ::
“Is this shirt cotton, or can it be felt?”
Medium
You: Are you from Tennessee?
Her: No why?
You: Because you only 10 I see in here
Worse
You are looking good tonight. Have you had an AIDS test recently?
Worst
I have been cruising the high school all day and you are the most decent one yet. Want a ride?
Excuse me does this cloth smell of ether?
Now, see, a lot of y’all aren’t specifying if your post contains “best” or “worst”. I mean, what if someone were lurking in the thread and trying to take notes?
Hilarity will ensue, and it will be awesome (for us at least…)
Don’t worry about the small stuff. I will pick you up in 20 minutes. Please bring a jar of Vaseline and a spatula. If you don’t have it, I will pick up them on the way over. What is the address for Mapquest? I wouldn’t want to pick up some random guy on the street. That would be icky. I have deeply held morality after all.
Aww, you charmer, you.
My favorite is partly physical:
“Hi, can I show you something? I’ll need your hand.” [Take her hand.] “So, there’s a bunny here” [point on her hand] “and a carrot here” [elsewhere on her hand] “and a river in between them” [draw line with finger on her hand.] “Now, the bunny really wants that carrot, but he can’t swim, and he can’t fly, and he can’t go around the hand. So what does he do?”
…presumably she says “I don’t know.”
“Actually, I don’t know either. I just wanted to hold your hand.”
I’ve never actually used that, but there was one occasion where a friend of mine and I were sitting in one corner of our school library, and another (female) classmate of ours was walking back and forth in front of us every few minutes for some reason, so we tried every pickup line we could remember on the poor girl. She turned a very lovely shade of red. Good memories.
The best pick-up line is a line of white powder.
As long as its not ajax bathroom cleaner
Declan
Dude: “Hey, I wanted to invite you back to my place for pizza and sex”
Chick: “What?!?!?”
Dude: “You don’t like pizza?”
Best: I lost my phone number- can I have yours?
Worst: What do I have to drink to get someone to sleep with around here?
Haaaaave you met Ted?
Best: “Let’s blow this pop stand.”
Worst: “Anybody ever tell you you look kinda like Carol Burnett? Yeah? Well, I’ve always fantasized about sucking her toes…Hey, can you do the voice, too?”
“Does this rag smell funny to you?”
Back when I was young… I had an “I’m with STUPID!” T-shirt, but the arrow pointed straight down…
It worked a charm…
FML
Best: Hi (with a smile and then look a little flustered) Ummm… Wow, you made me forget my best pick-up line… what about a drink now and i’ll come back later with something to say? (give 'em your best smile)
This one usually gets a smile from them, at least enough to start a conversation.
Worst: I might not be the most handsome of men, but I’m the one talking to you.
My friends and I came up with the 9 slap rule, which is ‘you might get slapped nine times but you’ll get a smile on the 10th go, hopefully’.
Usually true for me 
“Come on, you think you can do much better?”
Ladle, isn’t it? No Vaseline required, from what I’ve heard.
Ancient ones still make me laugh as long as the guy knows it’s funny and that it’s never going to work. The most recent was
Him: I love your hair. Do you have any French in you?
Me: No
Him: Would you like some?