Yikes!
Might be “Wife to two”; meaning the driver is part of a polyamorous grouping. That’d be fun too / two. 
DIZASTER
Might have been missing that final E. I’m sure about the Z, though
On an Acura SUV: NO NAM3S
IROOF4U on a pickup truck with ladders and tools in the back. There had once been company information on the tailgate, but most of the paint had peeled off.
Google AI says: “Terway is a self-developed Container Network Interface (CNI) plugin for Alibaba Cloud Container Service for Kubernetes (ACK).”
But from the other results, it also appears to be a surname of Indian origin.
So it’s probably one of those two. I think more likely the latter.
ARCGYKS
Absolutely no clue.
Although it was on a Kansas plate.
ArcGIS is the industry leading product in Geographic Information Systems. See GIS Software for Mapping and Spatial Analytics | Esri.
Maybe the driver works for them or works with their product but the ARCGIS plate was already was taken so they went with ARCGYS. Then tossed the K in there to make the S do double duty and keep it local.
A stretch, but IMO not a nutty stretch.
FAB LAN on a Ford Flex. No clue on that one.
9ER FAN with a big San Francisco 49ers sticker in the back window on some sort of SUV.
On a Yankees plate: JOE DI
I didn’t get a view of the driver, but it’s unlikely they ever saw the great DiMaggio play, given that his last season was 1951. So, a follower of Yankee history and tradition.
Or I suppose it’s possible the driver was Santiago the fisherman hoping to be worthy of the great DiMaggio who does all things perfectly. You never know.
MY PONY
(It was a mustang(
This morning I followed this one as I was driving to work:
BBOOP
Obviously a Betty Boop fan. Unless he/she likes shooting a BB gun at Alley Oop.
(Would anyone get those allusions today?)
Anyone who’s a geezer.
MELEE 2 on some crossover. A fan of the video game Super Smash Bros Melee?
SHILICK on a Ford Fusion. No idea what that one means. A strange spelling of Shylock?
Last few days’ haul:
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H1BACHI on a FL 7-character golf booster plate on a Ferrari. The meaning is obvious. The why is a headscratcher. Or maybe the meaning is H1B Achi, where his name is Achi, he came to the US on an H1B visa and done good, or ??? He was in his 30s.
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AD⎵⎵GUY on another FL 7-character golf booster plate on a Audi crossover.
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4⎵STOT on a FL standard plate on a Toyota 4Runner SUV. Guy looked like a 50ish middle manager. Some variation on a name?
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INSPIR3 on a FL standard plate on a generic car. Hard to say if the 3 represents an E or they simply picked the lowest available digit.
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TITAN⎵98 on a FL standard plate on a large Range Rover SUV. Graduating class of '98 from some college w the Titan team name? Wore jersey #98 playing for the NFL in Nashville?
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BAKU on a FL standard plate on a workin’ kinda pickup truck with some stuff in the back. Baku is the capital of Azerbaijan, and maybe he’s from there.
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4BL⎵OOM on a FL 7-character butterfly booster plate on a Lincoln crossover. Butterflies and flowers go together pretty well.
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IWAY on a FL standard plate on a Tesla. Maybe “intelligent way”, maybe I = me = “my way”?
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4SUNN on a FL 5-character surfing booster plate on a Mercedes coupe.
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SAMMY⎵B on a FL standard plate on a generic car.
Also saw one I’d posted before. I try to avoid repeats.
On a bright blue Camaro: APADAM. High school student? High school teacher?
4 C 
ERS on a Tesla Model Y. I assume “For sea lovers”, although there wasn’t anything particularly nautical about the car. I guess it could also be “4 sea lovers” as in a family of 4 who all love the ocean / beach.
I also saw something like ROMZOG or ROMEZOG, but I don’t think that’s quite right. I can’t remember exactly what it was. It was on a Dodge Challenger with a loud exhaust.
A Subaru WRX with: STOKWRX. Apparently potent enough just as it comes from the factory.
Yesterday I saw a shiny newish oversized white diesel pickup with a factory lift kit, custom oversized wheels & tires, and a Missouri plate reading MAGA48. The driver was a 60-ish large heavy guy with a red baseball cap. I could not get an angle to see what it said, but I have my suspicions.
What concerns me is he’s the 49th (at least) Missourian to think of getting a variation of MAGA on a personal plate. Or maybe, just maybe, he’s wanting trump to be the 48th president too.
Here’s your sign! Moron.
ROTTNEG on a big black SUV.
And on a little white hatchback: PERLA12. I’m not sure what was intended, but PERLA is medical shorthand for Pupils - Equal, Round, and responsive to Light and Accomodation. Probably something else. 