“I’ve got a bottle of Kahlua at my place. Wanna split it with me?”
Not sure if it will work. It worked on me, but I’m not a chick.
Oh, I don’t know…that one doesn’t seem so bad.
I heard this as -
“Did you wash your pants in Windex… cuz I can see myself in them.”
Well, maybe not a spoken line, but how’s about drawing a cartoon of yourself with your tongue hanging out and your eyes bulging out on a cocktail napkin with the caption “You’re beautiful!” and sending it over to my table with a drink? 
“Does this smell like chloroform?”
I do not now nor have I ever condoned date rape but this is the best freaking pick-up line ever if only because it made me fall on the floor laughing when I heard it.
How’s about walking up to your chick of choice, break the fourth wall and declare, “I’d buy that for a dollar”.
For some reason, the first thing I thought of when I saw the OP’s username and the question he was asking was:
“You know, I give really good piggy-back rides.”
I’m sure there’s an inneundo in there somewhere.
“For you, I might just go straight.”
“I just wrote some Austin Powers-Dr. Evil slash. Wanna help me act it out?”
I’ve always been partial to "Do you have some Indian in you? No? Do want one?
I almost told a girl today that she had a “tastee ass”. I mean, it was just such a fine ass…I don’t know what came over me, it was on the tip of my tongue… but I ended up complimenting her on her piercings instead. Thank God.
If I told you that you had a beautiful body would you hold it against me?
If seedy bars and dives are your thing, just come to Thailand. No need to open your mouth even. Not sure how “classy” the ladies will be, though.
Stateside, though, I always found just looking them in the eyes and licking my eyebrows worked wonders.
Ask her if she would like a Boulder handshake.
(I have no idea what a Boulder handshake is. It was my second day in Boulder CO and I was approached with this “offer”. I said no thank you. It might work, though).
Hello, I’m incredibly wealthy.
“Your skin is so soft and smooth. I’d tell you I want to peel it off and wear it for myself but you’d probably think I was weird.”
I can tell you from personal experience that this is not an effective pickup line!
Marc
eleaorigby, I’m almost sure that the “Boulder Handshake” is one of those leave-you-guessing type things. Legend (amongst very drunken boys) is that one party uses a hand to “shake” a part of the anatomy on the other side. Another version is more to-the-point. I have never seen or heard even semi-reliable stories of this actually happening.
Well, I’ve always (ie, once) had good luck with:
Me: So how’s that working out for you? 
Them: How’s what working out for me? 
Me: Being gorgeous. 
Them: Awww… :o
Note: She was already pretty knackered by this point, and had a pretty big crush on me, so I probably could have said that I just shit my pants and she still would have taken me back to her place.
Or how actually, you know, female.
“Bartender, another beer for me, and a rohypnotini for the lady!”
I’ve never had the guts to do this one, but I always figured if I’m ever single and a little drunk, I would try with…
“Hi there. My name’s Tristan… I saw you, figured I would come up, offer to buy you a drink and engage you in some conversation. See what kind of lady you are. You’re very attractive, and seem nifty, from what I can see so far. But also, I am impatient, so I was wondering if we could just go have sex, and I could get to know you better afterwards?”
also:
“…look, I’m a mature person. You’re a mature person. So let’s get out of here, and go do what mature people do.”